Radiobiology of tissue reactions

Radiobiology of tissue reactions.

Tissue effects of radiation exposure are observed in virtually all normal tissues, with interactions when several organs are involved. Early reactions occur in turnover tissues, where proliferative impairment results in hypoplasia; late reactions, based on combined parenchymal, vascular, and connective tissue changes, result in loss of function within the exposed volume; consequential late effe...

Skin and other reactions to radiotherapy--clinical presentation and radiobiology of skin reactions.

The skin represented the dose-limiting organ in radiotherapy over long periods of time. In the first third of the 20th century, radiotherapy was associated with deposition of significant radiation doses in the superficial compartments of the skin. Therefore, all major radiobiological principles, such as effects of fractionation on radiation sensitivity or volume/area effects, were initially bas...

Proton Radiobiology

In addition to the physical advantages (Bragg peak), the use of charged particles in cancer therapy can be associated with distinct biological effects compared to X-rays. While heavy ions (densely ionizing radiation) are known to have an energy- and charge-dependent increased Relative Biological Effectiveness (RBE), protons should not be very different from sparsely ionizing photons. A slightly...

Radiobiology of Radioresistant Glioblastoma

Therapy of glioblastoma has been very problematic with disappointing results using multiple therapeutic approaches. In general, glioblastomas are considered radioresistant tumors with different radiation modalities failing to control them in the clinic. However a comprehensive and detailed analysis of the radiosensitivity of glioblastoma cells has not been performed. We now present such an anal...

Handbook of Radiobiology